Example — B. subtilis lipase A
Job 41aa2db67df0 · 212 aa ·
5 designs/phenotype · 1 phenotype(s)
aggressiveness: Aggressive
mut %: 12.8
pLDDT: 90.4
TM-score: 0.987
MPNN score: 0.82
Δ charge: -2
MKTAYIAKQRQISFVKSQFSRQLEERLGLIEVQARIIYRGRDGTQDNLSGAEKIVQVKVKPLPDAQFEVVHSLAKWHGQTLGQHDFSGGEGLYTHMKALRPDEDRLSPLNSVAGDQWDWERVMIKGERQFSTLLSTVEAIPAGIKRTEAAYSEEFG
Wild-type (amber) overlaid with design (magma). Active-site residues highlighted.
aggressiveness: Bold
mut %: 10.9
pLDDT: 78.2
TM-score: 0.956
MPNN score: 1.03
Δ charge: 4
MKTAAIAKQRQQSFVKSHFSRQLEERLGLVEVQAPILSRAGDGTQDNSSGAWKAVQVKVKALPDAAFEVVLSLAKWKRQTLLQHDFSAGEGLYIHMKFLRPDEDRLSELLSVVVDQWDWERVMGDGERQFSCLKSTVEAIWAGQKATEAAVSEEFL
Wild-type (amber) overlaid with design (magma). Active-site residues highlighted.
aggressiveness: Moderate
mut %: 6.4
pLDDT: 75.7
TM-score: 0.862
MPNN score: 1.45
Δ charge: -4
MKTAYIAKQRQISFVKSHFSRQLEERLGLIEVQAPIISRVGDGTQDNLSYAEKAVQVKVKALNDAQFEVVHSLASWKRQTLVQHDFSAGEGLYTHMKALRPDEDRLSPLHSVYVDQWDWERVMNDGERPFSTLKSTVEAIWAGIKATEAAVSEEVG
Wild-type (amber) overlaid with design (magma). Active-site residues highlighted.
aggressiveness: Cautious
mut %: 5.1
pLDDT: 84.5
TM-score: 0.961
MPNN score: 1.34
Δ charge: -1
MKTAYIAKQREISFVKSHFSRQLEERLGLIEVQAPILSRVGDGTQDNLSGAEKAVQVLVKALPDAQFEVVHSLAKTKRNTTGQHDFSAGEGLYTHMKALRPDEDRLSPLHSVYVDQWDWSRVMGDGERQFSTLKSTVEAIWAGIKATEAAVSGEFG
Wild-type (amber) overlaid with design (magma). Active-site residues highlighted.
aggressiveness: Conservative
mut %: 3.2
pLDDT: 87.7
TM-score: 0.933
MPNN score: 1.45
Δ charge: 3
MKTAYIAKQRYINKVKSHFSRQLEERLGLIQVQAPILSRVGDGTQDNLSGAEKAVQVKVKALPDAQFEVVHSLAKWKRQTLGQHDFSAGEGLYTHMKALRPDEDRLSPLHSVYVDQWDWERVMGHGERQFSTLKSTVEAIWAGIKATEAAVSEEFG
Wild-type (amber) overlaid with design (magma). Active-site residues highlighted.