Example — B. subtilis lipase A

Job 5380aa7ca13b · 212 aa · 5 designs/phenotype · 1 phenotype(s)
done
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pLDDT: 81.3 TM-score: 0.969 MPNN score: 0.98 Δ charge: 1
MKTAYIAKQRQISFVKSHFSRQLEERPGLIEVQAPHLSRVGDGTQDNLSGAEKAIQEKVKALPDAQFEVVHSLAKWKRQTLGQHDFSAGEGLYTHMKALRPDEDRLSPLHSVYVDQWDWERVMGDGERQFSTLKSTVEAIWAGFKATEAEVSEEFG
Wild-type (amber) overlaid with design (magma). Active-site residues highlighted.

pLDDT: 87.7 TM-score: 0.889 MPNN score: 1.05 Δ charge: -4
MKTAYIAWQRQISFVKDHFSRQLEEDLGLIEVQAPILSRVGDGTVDNLSGAEKAVQVKVKALPDAQFEVVHSLAKWKRQTLGQHDFSAGEGLYTHMKALRPDEDRLSPLHSVYVDQWDWERQMGDGERQFSTLSSTVEAIYAGIKATEAAVSEEFG
Wild-type (amber) overlaid with design (magma). Active-site residues highlighted.

pLDDT: 87.3 TM-score: 0.897 MPNN score: 0.84 Δ charge: -4
MKTRYIAKQRQISFVKSHFSCQLEERLGLIAVRAPILSRVGDGTQDNLSGAEKAVQVKVKALPDAQFEVVHSLAKWKRQTLGQHDFSAGEGLYTAMKALRPDEDRLSPLHMVYEDQWDWERVMGDGERQFSTLKSTVEAIWAGIKATEAAVSEEFG
Wild-type (amber) overlaid with design (magma). Active-site residues highlighted.

pLDDT: 91.7 TM-score: 0.981 MPNN score: 0.82 Δ charge: 3
MKTAYIAKQRQISFVKSHFIRQLEMRNGLIEVIAPILSQTGDGTQDNLSGAEKAVQVKVKALPDAQFEVLHSLAKEKRQTLGQHDFSAGEGLYTHMKALRPDEDRLSPLHSVYVDQWDWERVMGDGERQFSTLVSTVEAIWAGIKATEAAVSEELG
Wild-type (amber) overlaid with design (magma). Active-site residues highlighted.

pLDDT: 70.6 TM-score: 0.961 MPNN score: 0.94 Δ charge: 2
MKTAYIAKCRQISFVKFHFSRQLEERLGLIEVQAPILSRVGDGTQDNLSGAEKAVQVKVKALPDAQFEVVHELAKWKRQTLGQHDFSAGEGLYTHMKAMRPDEDRLSPLHSVYVDQWDWERVMGDGERQFSTVKSTVEAIWAGIKATEAAVSEEFG
Wild-type (amber) overlaid with design (magma). Active-site residues highlighted.